‘Me spiego: da li conti che se fanno
secondo le statistiche d’adesso
risurta che te tocca un pollo all’anno:
e, se nun entra ne le spese tue,
t’entra ne la statistica lo stesso
perché c’è un antro che ne magna due.’
Da ‘La statistica’ di Trilussa
Chissà cosa avrebbe scritto di questi tempi il poeta e scrittore Carlo Alberto Camillo Mariano Salustri, passato alla storia con lo pseudonimo anagrammato di Trilussa, in merito all’utilizzo della media (storica) in questi terribili giorni che stiamo vivendo. Chissà come avrebbe commentato i dati, o meglio, le curve del contagio che vengono aggiornate giorno per giorno e che dettano i ritmi e le speranze di molti di noi quotidianamente. E chissà che cosa avrebbe scritto sui ricorrenti commenti di analisti, osservatori dei mercati finanziari e professionisti del risparmio gestito o della consulenza che cercano di ‘leggere’ tra i numeri delle crisi finanziarie dell’ultimo secolo il fondo del barile, il momento del riscatto dei mercati. Me lo immagino sornione con i suoi baffi all’insù sostituire ai polli i punti base degli indici e giudicare un po’ tutti questi ricercatori della verità perduta con quell’aria di sufficienza scanzonata e dissacrante che solo ‘i romani de roma de ‘na vorta’ potevano permettersi.
Eh si, perchè di tentativi di dare una spiegazione al momento attuale dei mercati se ne susseguono a migliaia ogni giorno. Ognuno di noi, tra letture di report di case di investimento più o meno blasonate, post sui social media di opinion leader e interviste di ‘strateghi’ dei mercati, ogni giorno legge ed ascolta le opinioni più svariate su quando finirà questo momento di tensione sui mercati finanziari e quanto veloce potrebbe essere il loro recupero.
[modalsurvey id=”1028824379″ style=”flat”]
Il lampione e l’ubriaco
Oltre a Trilussa, probabilmente avrebbe avuto qualcosa da ridire anche lo psicologo Paul Watzalawich che nel suo celebre libro ‘Istruzioni per renderci felici’ scrisse del paradosso dell’ubriaco e del lampione.
‘Sotto un lampione c’è un ubriaco che sta cercando qualcosa.
Si avvicina un poliziotto e gli chiede che cosa abbia perduto.
«Ho perso le chiavi di casa», risponde l’uomo, ed entrambi si mettono a cercarle.
Dopo aver guardato a lungo, il poliziotto chiede all’uomo ubriaco se è proprio sicuro di averle perse lì.
L’altro risponde:
«No, non le ho perse qui, ma là dietro», e indica un angolo buio in fondo alla strada.
«Ma allora perché diamine le sta cercando qui?»
«Perché qui c’è più luce!»’
In fin dei conti Watzalawich non ha fatto altro che abbellire quello che già il grande Mark Twain scriveva quasi 100 anni prima: La gente di solito usa le statistiche come un ubriaco i lampioni: più per sostegno che per illuminazione.
Sacrosanta verità! E quanto volte a quel ‘gente’ avremmo potuto sostituire ‘politici’, ‘burocrati’, persino ‘economisti’. E ‘analisti finanziari’.
E’ stato sempre un azzardo il confronto storico. Comodo, ma sempre un azzardo. Per il semplice fatto che implica un rincorrersi e ripetersi del passato con una certa ciclicità. A volte funziona, anche spesso in certi contesti, e tutto ciò può anche indurci ad essere estremamente confidenti. In fin dei conti, da molti è stato studiato il potere che hanno le aspettative di creare la realtà, dall’Effetto Placebo all’Effetto Nocebo, dall’Effetto Pigmalione all’Effetto Lucifero, dagli studi di Paul Watzlawick e Giorgio Nardone ai pioneristici contributi di Robert Merton e William Thomas. In finanza sono noti gli effetti delle aspettative autorealizzanti, grazie alle quali si sono moltiplicati analisti tecnici e ‘grafisti’. Ma ha senso leggere e rileggere con tanta enfasi i dati storici in questo momento attuale?
Mi riferisco ai numerosi articoli e studi che circolano in questi giorni che analizzano e mettono a confronto le varie crisi economiche e finanziare che sono accadute negli ultimi 100 anni, con l’obiettivo di studiarne gli effetti in termini di perdita dei mercati finanziari e tempo di recupero dei livelli pre-crisi.
Ed è qui che entrano in gioco le medie. Perdita media dei mercati, tempo medio di recupero degli stessi. Quello che stiamo vivendo è una crisi sanitaria che ha generato una crisi economica da offerta senza precedenti che dovrebbe indurre a tralasciare qualsiasi confronto storico. Ovvio, il ‘lampione’ di cui sopra è comodo, sta lì, ci attrae, ci induce in tentazione, ma è dannatamente fuorviante.
Fra dieci anni ci ricorderemo di essere stati tutti più bravi.
E non cadiamo nella dolce trappola del ricordo, di come abbiamo gestito e previsto ad esempio la crisi del 2008 e del 2011. Il problema si chiama ‘hindsight bias’, cioè ci si riferisce a quel giudizio retrospettico che ci porta erroneamente a credere che il risultato di un evento fosse già ovvio e prevedibile nel momento in cui abbiamo preso la decisione, mentre in verità era giustificabile e comprensibile solo a posteriori. Proviamo a spostarci idealmente nel 2030 e di ricordare i fatti del 2020. Probabilmente, molti di noi tenderanno a ricostruire i fatti come prevedibili, che non poteva essere altrimenti, che i mercati non potevano che fare questo. Che i mercati, poi, non potevano che rimbalzare nel modo in cui hanno fatto, etc etc.
Ma non ci facciamo ingannare. In finanza comportamentale questo bias è ben noto, come molti altri. Le variabili in gioco in questo momento sono talmente tante che è impossibile fare una sintesi di quello che potrebbe accadere. In realtà, siamo quasi all’oscuro di cosa possa succedere ai mercati finanziari, ma siamo quasi certi che non accadrà ciò che è avvenuto nelle passate crisi. E non ha neanche senso sedersi al tavolo da pocker senza conoscere le regole del gioco.
Chi è il pollo?
C’è un detto per chi gioca a pocker. Se ti siedi al tavolo da gioco e dopo 10 minuti non hai capito chi è il pollo, allora il pollo sei tu! E in questo momento, tutti gli ‘avversari’ sono troppo imprevedibili per comprendere le loro ‘tecniche di gioco’.
L’avversario si chiama ‘tempo’, ma quanto durerà questa crisi?; si chiama ‘propensione al consumo’, ma quale sarà la volontà di consumare, anche beni durevoli, passata la tempesta covid-19; si chiama ‘investimenti’, ma quali e quante saranno le aziende che potranno fare investimenti durevoli e redditizi dopo tutto ciò?
Fare oggi previsioni sui mercati è come fare un ‘all in’ senza avere visto neanche le carte in mano. Al netto degli interventi di politica monetaria e fiscale, solo un evento permetterà a tutti, analisti compresi, di fare previsioni sulle variabili che sono alla base di qualunque asset finanziario e questo evento si chiama ‘cura’ e/o ‘vaccino’. Finchè vi sarà un problema di natura sanitaria di questo tipo, con i rischi di ondate successive anche nei Paesi che ad oggi hanno iniziato a circoscrivere il fenomeno, la volatilità e il downside risk la faranno da padroni. Prendiamoci tutti una sana pausa di riflessione e magari rileggiamoci anche i polli di Trilussa, ma evitiamo di essere i polli delle medie statistiche.
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**Manufacturing Methylamines:**
There are multiple approaches to producing methylamines, such as combining ammonia with methanol or reducing nitroalkanes using hydrogen in the presence of a metallic catalyst. The most widespread method in the industry entails reacting methanol with ammonia alongside a heterogeneous catalyst, which results in a mix of methylamines. Through fractionation, specific methylamine variants can be segregated.
**Chemical Traits and Utilization:**
Methylamines exhibit chemical characteristics due to their amine group, making them essential components in organic chemistry. Their capacity to act as nucleophiles, engaging with electrophiles, is pivotal for generating pharmaceuticals, pesticides, and unique chemicals. These compounds also serve as intermediates in creating surfactants, solvents, and polymers, highlighting their critical role in a variety of industrial operations.
**Comparative Overview:**
When compared to other amine derivatives like ethylamines or propylamines, methylamines have certain benefits such as increased reactivity and more stability under usual conditions. Their straightforward production methods and broad availability enhance their appeal for chemical manufacturing. Nevertheless, the associated risks of toxicity and environmental harm call for rigorous safety protocols and eco-friendly practices in their handling and application.
**Future Outlook and Final Thoughts:**
Future research is directed towards uncovering new methods of synthesis and broadening the uses of methylamines in burgeoning areas like catalysis and materials science. Leveraging their chemical adaptability and refining production techniques could pave the way for breakthroughs and tackle global challenges sustainably.
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Pharmacology’s Role and Drug Development in Modern Society
Pharmacology, the science of drugs and their effects on living systems, plays a pivotal role in modern society. With an ever-increasing burden of diseases and health conditions, the development of new medications is vital for improving healthcare outcomes and enhancing quality of life. This article explores the significance of pharmacology and the process of drug development in addressing contemporary health challenges.
**Understanding Pharmacology:**
Pharmacology encompasses a multidisciplinary approach, combining aspects of biology, chemistry, physiology, and pathology to study how drugs interact with biological systems. It delves into the mechanisms of action, therapeutic effects, and potential side effects of medications. By comprehensively understanding these factors, pharmacologists strive to develop safer and more effective drugs for treating various ailments.
**Importance of Drug Development:**
The development of new drugs is essential for combating both prevalent and emerging health threats. Chronic diseases such as cardiovascular disorders, cancer, diabetes, and respiratory ailments continue to impose a significant burden on global health. Moreover, the emergence of novel pathogens, antimicrobial resistance, and environmental factors further underscore the need for innovative pharmaceutical solutions.
**Phases of Drug Development:**
The journey from drug discovery to market availability is a complex and rigorous process comprising several distinct phases:
1. **Drug Discovery:** Scientists identify potential drug candidates through various means, including screening natural compounds, designing molecules using computational methods, or repurposing existing drugs for new indications.
2. **Preclinical Research:** Promising drug candidates undergo extensive laboratory testing to assess their safety, efficacy, and pharmacokinetic properties in cellular and animal models.
3. **Clinical Trials:** Drug candidates that demonstrate favorable preclinical results advance to clinical trials, which consist of three sequential phases:
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– **Phase II:** Evaluates the drug’s efficacy and side effects in a larger group of individuals with the targeted disease or condition.
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4. **Regulatory Approval:** Following successful completion of clinical trials, pharmaceutical companies submit comprehensive data to regulatory authorities such as the FDA in the United States or the EMA in Europe for approval to market the drug.
5. **Post-Marketing Surveillance:** Even after approval, ongoing monitoring is crucial to detect any unforeseen adverse effects and ensure the drug’s continued safety and efficacy in real-world settings.
**Challenges and Future Directions:**
Despite significant advancements in pharmacology and drug development, several challenges persist. These include escalating research and development costs, regulatory hurdles, ethical considerations, and the increasing complexity of diseases. Additionally, disparities in access to medications and healthcare services remain a global concern.
Looking ahead, emerging technologies such as precision medicine, gene editing, and artificial intelligence offer promising avenues for personalized therapies and targeted drug development. Collaborative efforts among researchers, clinicians, pharmaceutical companies, and policymakers are imperative to address these challenges and harness the full potential of pharmacology in improving global health outcomes.
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